53
11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14349 | Auristatin F | Microtubule Associated | Cytoskeletal Signaling |
Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。 | |||
T14348 |
Auristatin E
|
Microtubule Associated | Cytoskeletal Signaling |
Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂,具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物,是抗体-药物偶联物中的细胞毒素。 | |||
T38889 |
Thailanstatin A
|
||
Thailanstatin A 是真核 RNA 剪接抑制剂,IC50为650 nM,通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合,可产生“无连接子” ADC。 | |||
T11249L |
Dxd
Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ |
Topoisomerase | DNA Damage/DNA Repair |
Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂,IC50值为 0.31 μM,用作HER2靶向ADC 的偶联药物。 | |||
T15141 |
DM4
Ravtansine,美登素 DM4 |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
DM4 (Ravtansine)可用于制备抗体药物偶联物,是抗微管蛋白剂。 它抑制细胞分裂。 | |||
T11120 |
Duocarmycin TM
|
DNA Alkylation; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。 | |||
T3256 |
MMAF
一甲基澳瑞他汀 F,MonoMethyl auristatin F |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
MMAF (MonoMethyl auristatin F) 是一种抗有丝分裂剂,通过阻断微管蛋白的聚合来抑制细胞分裂,用作抗肿瘤药物和抗体偶联药物的细胞毒性成分。 | |||
T12081 |
MMAF-OMe
Monomethyl auristatin F methyl ester |
||
MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂,能够抑制 MDAMB435/5T4,MDAMB361DYT2,MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞,IC50值分别为 0.056 nM,0.166 nM,0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。 | |||
T8003 |
Methotrexate disodium
|
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate disodium 是一种叶酸类似物代谢抑制剂,具有免疫抑制剂和抗肿瘤特性,用于类风湿关节炎和研究多种癌症。 | |||
T16557 |
PNU-159682
|
Topoisomerase | DNA Damage/DNA Repair |
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。 | |||
T1992 |
Mertansine
DM1,Maytansinoid DM1 |
Microtubule Associated | Cytoskeletal Signaling |
Mertansine (DM1) 是一种微管蛋白抑制剂,也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上,形成抗体偶联药物。 | |||
T14858 |
Calicheamicin
Calicheamicin γ1,卡奇霉素 |
Others | Others |
Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素,可引起DNA 双链断裂,抑制DNA 合成。 | |||
T21408 |
DM1-SMe
DM1-SSMe |
Microtubule Associated | Cytoskeletal Signaling |
DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍,在一组人类肿瘤细胞系中,DM1-SMe 的 IC50 为 0.003 至 0.01 nM。 | |||
T6897 |
Monomethyl auristatin E
一甲基澳瑞他汀E,Vedotin,MMAE |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Monomethyl auristatin E (MMAE) 是海兔毒素 10 的合成衍生物,是一种抗有丝分裂剂,通过阻断微管蛋白的聚合来抑制细胞分裂,并且还具有抑制抗体-药物偶联物的活性。 | |||
T1910 |
Ansamitocin P 3'
Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3' |
Microtubule Associated | Cytoskeletal Signaling |
Ansamitocin P 3' (Maytansinol butyrate) 是一种具有抗肿瘤活性的抗体-药物偶联细胞毒素。 | |||
T4677 |
MMAD
Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10 |
Microtubule Associated | Cytoskeletal Signaling |
MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂,是抗体药物偶联物中的一种毒素有效载荷。 | |||
T1485 |
Methotrexate
NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。 | |||
T41248 |
Thiocolchicine
|
Microtubule Associated | Cytoskeletal Signaling |
Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。 | |||
T10972 |
DC4
|
Others | Others |
DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors. | |||
T77889 |
NH2-methylpropanamide-Exatecan TFA
|
Topoisomerase | DNA Damage/DNA Repair |
NH2-methylpropanamide-Exatecan (TFA) 为对异丁酰胺进行修饰的Exatecan,属于ADC毒素(ADC Cytotoxin),应用于ADC合成中。该化合物作为DNA拓扑异构酶I(topoisomerase I)抑制剂,具有2.2 μM(0.975 μg/mL)的IC50,适用于癌症研究。 | |||
T19300 |
Duocarmycin Analog
|
DNA Alkylation | DNA Damage/DNA Repair |
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin. | |||
T18292 |
Mal-PEG4-VC-PAB-DMEA-PNU-159682
|
Others | Others |
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, DMEA-PNU-159682, is derived from metabolites of nemorubicin (MMDX) found in liver microsomes, as well as the ADC cytotoxin PNU-159682[1]. | |||
T17802 |
DBCO-PEG4-VC-PAB-DMEA-PNU-159682
|
Others | Others |
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1]. | |||
T39582 |
2',3'-cGAMP-C2-SH
2',3'-cGAMP-C2-SH |
||
2', 3'-cGAMP-C2-SH is a ADC cytotoxin. | |||
T12813L |
Seco-Duocarmycin SA
|
DNA Alkylation | DNA Damage/DNA Repair |
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin. | |||
T13658 |
DMEA-PNU-159682
|
Others | Others |
DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule, including neomycin (MMDX) metabolites from liver microsomes and effective ADC cytotoxin PNU-159682. | |||
T63713 |
Mytoxin B
|
||
Mytoxin B 是一种大环内脂,作用与 LY294002 相似,也是一种 ADC 细胞毒素 (ADC cytotoxin)。Mytoxin B 能够利用 PI3K/Akt 通路,进而诱导细胞凋亡 (apoptosis)。 | |||
T18302 |
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
|
Others | Others |
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 encompasses metabolites of nemorubicin (MMDX) derived from liver microsomes, as well as the ADC cytotoxin PNU-159682[1]. | |||
T12813 |
(S)-Seco-Duocarmycin SA
|
Others | Others |
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates. | |||
T10640 |
C-11
|
Others | Others |
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines. | |||
T18246 |
Mal-C2-Gly3-EDA-PNU-159682
|
Others | Others |
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682. | |||
T38430 |
Tubulysin IM-2
|
||
Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins . | |||
T74177 | Modified MMAF | ||
Modified MMAF 是一种用于构建 Antibody-drug Conjugate (ADC) 的 ADC 细胞毒素,适用于癌症靶向研究。 | |||
T40191 |
17-GMB-APA-GA
|
||
17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection. | |||
T19254 | Cyclooctyne-O-NHS ester | Others | Others |
Cycloctyne-O-NHS ester is a derivative of cyclooctyne, which will seriously damage HEK293 cells and be used as ADC cytotoxin. | |||
T39138 |
Muscotoxin A
|
||
Muscotoxin A is an ADC cytotoxin with lipopeptide properties that effectively permeabilizes mammalian cell membranes, ultimately inducing necrotic cell death. | |||
T60321 |
Tubulysin IM-3
|
||
Tubulysin IM-3 是ADC 细胞毒素 (ADC Cytotoxin), 也是一种微管蛋白结合剂。Tubulysin IM-3 可用作抗微管毒素 (anti-microtubule toxins)。 | |||
T73947 | Tubulysin IM-1 | ||
Tubulysin IM-1 是 ADC 细胞毒素 (ADC Cytotoxin), 也是一种微管蛋白结合剂,用作抗微管毒素 (anti-microtubule toxins)。 | |||
T18304 |
Mal-VC-PAB-ABAEP-Azonafide
|
Others | Others |
Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1]. | |||
T74367 |
SC209
|
||
SC209 是个 ADC 细胞毒素, 用于合成抗 EGFR 抗体-活性分子偶联 ADC。SC209 是 STRO-002 的代谢物。 | |||
T17740 | Cyclooctyne-O-PFP ester | Others | Others |
Cyclooctyne-O-PFP ester is a used as an ADC cytotoxin, which connects antibody and linker[1]. | |||
T77901 |
Ac-Exatecan
|
Topoisomerase | DNA Damage/DNA Repair |
Ac-Exatecan是经乙酰化改良的Exatecan,后者(DX-8951)为ADC生产中普遍使用的毒素组分(ADC Cytotoxin),同时作为DNA拓扑异构酶I(topoisomerase I)的抑制剂,其IC50值为2.2 μM。 | |||
T77874 |
Maytansinoid B
|
||
Maytansinoid B 是一种ADC Cytotoxin,用于形成与抗体结合的Antibody-Drug Conjugates (ADCs)。它是一种抗有丝分裂剂,能够结合微管蛋白并阻断其组装,诱导细胞周期在G2/M阶段停滞,进而触发细胞凋亡(apoptosis)。 | |||
T82382 |
Fmoc-MMAF-OMe
|
||
Fmoc-MMAF-OMe,一种具有Fmoc保护基团的抗癌剂和微管蛋白聚合抑制剂,其活性成分MMAF作为经典抗体偶联药物(ADCs)中的细胞毒性(ADC Cytotoxin)组分。 | |||
T77872 |
S-Me-DM4
|
||
S-Me-DM4是DM4在胞内酶作用下发生S-甲基化反应形成的代谢产物。DM4本身是一种具有强细胞毒性的含硫醇类微管解聚剂,并可作为ADC Cytotoxin分子应用。 | |||
T10970 | DC1 | Others | Others |
DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. | |||
T11046 |
Dimethyl-SGD-1882
Dimethyl-PBD dimer |
Others | Others |
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication. | |||
T15158 |
Dolastatin 15
DLS 15 |
Others | Others |
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m | |||
T10969 |
DC1SMe
|
Others | Others |
DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 values of Ramos, Namalwa, HL60 / s | |||
T61390 |
D18
|
||
D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0968 |
Paclitaxel
Taxol,紫杉醇,NSC 125973 |
Apoptosis; Microtubule Associated; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling |
Paclitaxel (Taxol) 属于天然产物,是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性;通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等,导致细胞死亡。 | |||
T16016 |
Maytansinol
美登醇,Ansamitocin P-0 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用,用于果蝇和人类癌细胞。 | |||
TP1180 |
Dolastatin 10
尾海兔素10,NSC 376128,DLS 10 |
Microtubule Associated | Cytoskeletal Signaling |
Dolastatin 10 (DLS 10) 是一种多肽,可以抑制微管蛋白聚合,显示除抗有丝分裂的活性。 | |||
T1123 |
Camptothecin
NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT |
Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal | Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology |
Camptothecin (CPT) 属于生物碱类天然产物,是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM),具有特异性。Camptothecin 具有抗肿瘤活性,可以诱导细胞凋亡。 | |||
T1703 |
SN-38
7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38 |
DNA/RNA Synthesis; Topoisomerase; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物,可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性,可以诱导细胞自噬。 | |||
T1511 |
Daunorubicin hydrochloride
Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin |
Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物,可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T5749 |
10-Deacetyl-7-xylosyl paclitaxel
10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物,具有改进的药理特性和更高的水溶性,用于治疗癌症。 | |||
T1456 |
Doxorubicin
Hydroxydaunorubicin,阿霉素,Adriamycin |
Topoisomerase; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。 | |||
T73915 | Luisol A | ||
Luisol A 是一种芳香族四醇,是链霉菌属的河口海洋放线菌的主要代谢产物。Luisol A 是一种蒽醌抗生素类似物,是 ADC 细胞毒素 (ADC Cytotoxin)。 | |||
T39562 | γ-Amanitin | ||
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. |