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53

抑制剂 & 化合物

11

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Cat. No. Product Name Target Signaling Pathways
T14349 Auristatin F

Microtubule Associated Cytoskeletal Signaling
Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。
T14348 Auristatin E

Microtubule Associated Cytoskeletal Signaling
Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂,具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物,是抗体-药物偶联物中的细胞毒素。
T38889 Thailanstatin A

Thailanstatin A 是真核 RNA 剪接抑制剂,IC50为650 nM,通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合,可产生“无连接子” ADC
T11249L Dxd

Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ

Topoisomerase DNA Damage/DNA Repair
Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂,IC50值为 0.31 μM,用作HER2靶向ADC 的偶联药物。
T15141 DM4

Ravtansine,美登素 DM4

Others; Microtubule Associated Cytoskeletal Signaling; Others
DM4 (Ravtansine)可用于制备抗体药物偶联物,是抗微管蛋白剂。 它抑制细胞分裂。
T11120 Duocarmycin TM

DNA Alkylation; Antibiotic DNA Damage/DNA Repair; Microbiology/Virology
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。
T3256 MMAF

一甲基澳瑞他汀 F,MonoMethyl auristatin F

Others; Microtubule Associated Cytoskeletal Signaling; Others
MMAF (MonoMethyl auristatin F) 是一种抗有丝分裂剂,通过阻断微管蛋白的聚合来抑制细胞分裂,用作抗肿瘤药物和抗体偶联药物的细胞毒性成分。
T12081 MMAF-OMe

Monomethyl auristatin F methyl ester

MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂,能够抑制 MDAMB435/5T4,MDAMB361DYT2,MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞,IC50值分别为 0.056 nM,0.166 nM,0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。
T8003 Methotrexate disodium

Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Methotrexate disodium 是一种叶酸类似物代谢抑制剂,具有免疫抑制剂和抗肿瘤特性,用于类风湿关节炎和研究多种癌症。
T16557 PNU-159682

Topoisomerase DNA Damage/DNA Repair
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。
T1992 Mertansine

DM1,Maytansinoid DM1

Microtubule Associated Cytoskeletal Signaling
Mertansine (DM1) 是一种微管蛋白抑制剂,也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上,形成抗体偶联药物。
T14858 Calicheamicin

Calicheamicin γ1,卡奇霉素

Others Others
Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素,可引起DNA 双链断裂,抑制DNA 合成。
T21408 DM1-SMe

DM1-SSMe

Microtubule Associated Cytoskeletal Signaling
DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍,在一组人类肿瘤细胞系中,DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T6897 Monomethyl auristatin E

一甲基澳瑞他汀E,Vedotin,MMAE

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
Monomethyl auristatin E (MMAE) 是海兔毒素 10 的合成衍生物,是一种抗有丝分裂剂,通过阻断微管蛋白的聚合来抑制细胞分裂,并且还具有抑制抗体-药物偶联物的活性。
T1910 Ansamitocin P 3'

Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'

Microtubule Associated Cytoskeletal Signaling
Ansamitocin P 3' (Maytansinol butyrate) 是一种具有抗肿瘤活性的抗体-药物偶联细胞毒素。
T4677 MMAD

Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10

Microtubule Associated Cytoskeletal Signaling
MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂,是抗体药物偶联物中的一种毒素有效载荷。
T1485 Methotrexate

NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377

Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。
T41248 Thiocolchicine

Microtubule Associated Cytoskeletal Signaling
Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T10972 DC4

Others Others
DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors.
T77889 NH2-methylpropanamide-Exatecan TFA

Topoisomerase DNA Damage/DNA Repair
NH2-methylpropanamide-Exatecan (TFA) 为对异丁酰胺进行修饰的Exatecan,属于ADC毒素(ADC Cytotoxin),应用于ADC合成中。该化合物作为DNA拓扑异构酶I(topoisomerase I)抑制剂,具有2.2 μM(0.975 μg/mL)的IC50,适用于癌症研究。
T19300 Duocarmycin Analog

DNA Alkylation DNA Damage/DNA Repair
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T18292 Mal-PEG4-VC-PAB-DMEA-PNU-159682

Others Others
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, DMEA-PNU-159682, is derived from metabolites of nemorubicin (MMDX) found in liver microsomes, as well as the ADC cytotoxin PNU-159682[1].
T17802 DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Others Others
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1].
T39582 2',3'-cGAMP-C2-SH

2',3'-cGAMP-C2-SH

2', 3'-cGAMP-C2-SH is a ADC cytotoxin.
T12813L Seco-Duocarmycin SA

DNA Alkylation DNA Damage/DNA Repair
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T13658 DMEA-PNU-159682

Others Others
DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule, including neomycin (MMDX) metabolites from liver microsomes and effective ADC cytotoxin PNU-159682.
T63713 Mytoxin B

Mytoxin B 是一种大环内脂,作用与 LY294002 相似,也是一种 ADC 细胞毒素 (ADC cytotoxin)。Mytoxin B 能够利用 PI3K/Akt 通路,进而诱导细胞凋亡 (apoptosis)。
T18302 Mal-Phe-C4-VC-PAB-DMEA-PNU-159682

Others Others
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 encompasses metabolites of nemorubicin (MMDX) derived from liver microsomes, as well as the ADC cytotoxin PNU-159682[1].
T12813 (S)-Seco-Duocarmycin SA

Others Others
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T10640 C-11

Others Others
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines.
T18246 Mal-C2-Gly3-EDA-PNU-159682

Others Others
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682.
T38430 Tubulysin IM-2

Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins .
T74177 Modified MMAF

Modified MMAF 是一种用于构建 Antibody-drug Conjugate (ADC) 的 ADC 细胞毒素,适用于癌症靶向研究。
T40191 17-GMB-APA-GA

17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.
T19254 Cyclooctyne-O-NHS ester

Others Others
Cycloctyne-O-NHS ester is a derivative of cyclooctyne, which will seriously damage HEK293 cells and be used as ADC cytotoxin.
T39138 Muscotoxin A

Muscotoxin A is an ADC cytotoxin with lipopeptide properties that effectively permeabilizes mammalian cell membranes, ultimately inducing necrotic cell death.
T60321 Tubulysin IM-3

Tubulysin IM-3 是ADC 细胞毒素 (ADC Cytotoxin), 也是一种微管蛋白结合剂。Tubulysin IM-3 可用作抗微管毒素 (anti-microtubule toxins)。
T73947 Tubulysin IM-1

Tubulysin IM-1 是 ADC 细胞毒素 (ADC Cytotoxin), 也是一种微管蛋白结合剂,用作抗微管毒素 (anti-microtubule toxins)。
T18304 Mal-VC-PAB-ABAEP-Azonafide

Others Others
Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1].
T74367 SC209

SC209 是个 ADC 细胞毒素, 用于合成抗 EGFR 抗体-活性分子偶联 ADC。SC209 是 STRO-002 的代谢物。
T17740 Cyclooctyne-O-PFP ester

Others Others
Cyclooctyne-O-PFP ester is a used as an ADC cytotoxin, which connects antibody and linker[1].
T77901 Ac-Exatecan

Topoisomerase DNA Damage/DNA Repair
Ac-Exatecan是经乙酰化改良的Exatecan,后者(DX-8951)为ADC生产中普遍使用的毒素组分(ADC Cytotoxin),同时作为DNA拓扑异构酶I(topoisomerase I)的抑制剂,其IC50值为2.2 μM。
T77874 Maytansinoid B

Maytansinoid B 是一种ADC Cytotoxin,用于形成与抗体结合的Antibody-Drug Conjugates (ADCs)。它是一种抗有丝分裂剂,能够结合微管蛋白并阻断其组装,诱导细胞周期在G2/M阶段停滞,进而触发细胞凋亡(apoptosis)。
T82382 Fmoc-MMAF-OMe

Fmoc-MMAF-OMe,一种具有Fmoc保护基团的抗癌剂和微管蛋白聚合抑制剂,其活性成分MMAF作为经典抗体偶联药物(ADCs)中的细胞毒性(ADC Cytotoxin)组分。
T77872 S-Me-DM4

S-Me-DM4是DM4在胞内酶作用下发生S-甲基化反应形成的代谢产物。DM4本身是一种具有强细胞毒性的含硫醇类微管解聚剂,并可作为ADC Cytotoxin分子应用。
T10970 DC1

Others Others
DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.
T11046 Dimethyl-SGD-1882

Dimethyl-PBD dimer

Others Others
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication.
T15158 Dolastatin 15

DLS 15

Others Others
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
T10969 DC1SMe

Others Others
DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 values of Ramos, Namalwa, HL60 / s
T61390 D18

D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].

化合物

Auristatin F
Cat.No: T14349
Synonym:
Target: Microtubule Associated
Auristatin E
Cat.No: T14348
Synonym:
Target: Microtubule Associated
Thailanstatin A
Cat.No: T38889
Synonym:
Target:
Dxd
Cat.No: T11249L
Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ
Target: Topoisomerase
DM4
Cat.No: T15141
Synonym: Ravtansine,美登素 DM4
Target: Others, Microtubule Associated
Duocarmycin TM
Cat.No: T11120
Synonym:
Target: DNA Alkylation, Antibiotic
MMAF
Cat.No: T3256
Synonym: 一甲基澳瑞他汀 F,MonoMethyl auristatin F
Target: Others, Microtubule Associated
MMAF-OMe
Cat.No: T12081
Synonym: Monomethyl auristatin F methyl ester
Target:
Methotrexate disodium
Cat.No: T8003
Synonym:
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
PNU-159682
Cat.No: T16557
Synonym:
Target: Topoisomerase
Mertansine
Cat.No: T1992
Synonym: DM1,Maytansinoid DM1
Target: Microtubule Associated
Calicheamicin
Cat.No: T14858
Synonym: Calicheamicin γ1,卡奇霉素
Target: Others
DM1-SMe
Cat.No: T21408
Synonym: DM1-SSMe
Target: Microtubule Associated
Monomethyl auristatin E
Cat.No: T6897
Synonym: 一甲基澳瑞他汀E,Vedotin,MMAE
Target: Apoptosis, Microtubule Associated
Ansamitocin P 3'
Cat.No: T1910
Synonym: Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'
Target: Microtubule Associated
MMAD
Cat.No: T4677
Synonym: Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10
Target: Microtubule Associated
Methotrexate
Cat.No: T1485
Synonym: NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Thiocolchicine
Cat.No: T41248
Synonym:
Target: Microtubule Associated
DC4
Cat.No: T10972
Synonym:
Target: Others
NH2-methylpropanamide-Exatecan TFA
Cat.No: T77889
Synonym:
Target: Topoisomerase
Duocarmycin Analog
Cat.No: T19300
Synonym:
Target: DNA Alkylation
Mal-PEG4-VC-PAB-DMEA-PNU-159682
Cat.No: T18292
Synonym:
Target: Others
DBCO-PEG4-VC-PAB-DMEA-PNU-159682
Cat.No: T17802
Synonym:
Target: Others
2',3'-cGAMP-C2-SH
Cat.No: T39582
Synonym: 2',3'-cGAMP-C2-SH
Target:
Seco-Duocarmycin SA
Cat.No: T12813L
Synonym:
Target: DNA Alkylation
DMEA-PNU-159682
Cat.No: T13658
Synonym:
Target: Others
Mytoxin B
Cat.No: T63713
Synonym:
Target:
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
Cat.No: T18302
Synonym:
Target: Others
(S)-Seco-Duocarmycin SA
Cat.No: T12813
Synonym:
Target: Others
C-11
Cat.No: T10640
Synonym:
Target: Others
Mal-C2-Gly3-EDA-PNU-159682
Cat.No: T18246
Synonym:
Target: Others
Tubulysin IM-2
Cat.No: T38430
Synonym:
Target:
Modified MMAF
Cat.No: T74177
Synonym:
Target:
17-GMB-APA-GA
Cat.No: T40191
Synonym:
Target:
Cyclooctyne-O-NHS ester
Cat.No: T19254
Synonym:
Target: Others
Muscotoxin A
Cat.No: T39138
Synonym:
Target:
Tubulysin IM-3
Cat.No: T60321
Synonym:
Target:
Tubulysin IM-1
Cat.No: T73947
Synonym:
Target:
Mal-VC-PAB-ABAEP-Azonafide
Cat.No: T18304
Synonym:
Target: Others
SC209
Cat.No: T74367
Synonym:
Target:
Cyclooctyne-O-PFP ester
Cat.No: T17740
Synonym:
Target: Others
Ac-Exatecan
Cat.No: T77901
Synonym:
Target: Topoisomerase
Maytansinoid B
Cat.No: T77874
Synonym:
Target:
Fmoc-MMAF-OMe
Cat.No: T82382
Synonym:
Target:
S-Me-DM4
Cat.No: T77872
Synonym:
Target:
DC1
Cat.No: T10970
Synonym:
Target: Others
Dimethyl-SGD-1882
Cat.No: T11046
Synonym: Dimethyl-PBD dimer
Target: Others
Dolastatin 15
Cat.No: T15158
Synonym: DLS 15
Target: Others
DC1SMe
Cat.No: T10969
Synonym:
Target: Others
D18
Cat.No: T61390
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T0968 Paclitaxel

Taxol,紫杉醇,NSC 125973

Apoptosis; Microtubule Associated; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling
Paclitaxel (Taxol) 属于天然产物,是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性;通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等,导致细胞死亡。
T16016 Maytansinol

美登醇,Ansamitocin P-0

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用,用于果蝇和人类癌细胞。
TP1180 Dolastatin 10

尾海兔素10,NSC 376128,DLS 10

Microtubule Associated Cytoskeletal Signaling
Dolastatin 10 (DLS 10) 是一种多肽,可以抑制微管蛋白聚合,显示除抗有丝分裂的活性。
T1123 Camptothecin

NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT

Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
Camptothecin (CPT) 属于生物碱类天然产物,是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM),具有特异性。Camptothecin 具有抗肿瘤活性,可以诱导细胞凋亡。
T1703 SN-38

7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38

DNA/RNA Synthesis; Topoisomerase; Autophagy Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物,可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性,可以诱导细胞自噬。
T1511 Daunorubicin hydrochloride

Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物,可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
T1020 Doxorubicin hydrochloride

Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。
T5749 10-Deacetyl-7-xylosyl paclitaxel

10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Others; Microtubule Associated Cytoskeletal Signaling; Others
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物,具有改进的药理特性和更高的水溶性,用于治疗癌症。
T1456 Doxorubicin

Hydroxydaunorubicin,阿霉素,Adriamycin

Topoisomerase; AMPK Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。
T73915 Luisol A

Luisol A 是一种芳香族四醇,是链霉菌属的河口海洋放线菌的主要代谢产物。Luisol A 是一种蒽醌抗生素类似物,是 ADC 细胞毒素 (ADC Cytotoxin)。
T39562 γ-Amanitin

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.

天然产物

Paclitaxel
Cat.No: T0968
Synonym: Taxol,紫杉醇,NSC 125973
Target: Apoptosis, Microtubule Associated, Autophagy
Maytansinol
Cat.No: T16016
Synonym: 美登醇,Ansamitocin P-0
Target: Apoptosis, Microtubule Associated
Dolastatin 10
Cat.No: TP1180
Synonym: 尾海兔素10,NSC 376128,DLS 10
Target: Microtubule Associated
Camptothecin
Cat.No: T1123
Synonym: NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT
Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal
SN-38
Cat.No: T1703
Synonym: 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38
Target: DNA/RNA Synthesis, Topoisomerase, Autophagy
Daunorubicin hydrochloride
Cat.No: T1511
Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin
Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Doxorubicin hydrochloride
Cat.No: T1020
Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127
Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy
10-Deacetyl-7-xylosyl paclitaxel
Cat.No: T5749
Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside
Target: Others, Microtubule Associated
Doxorubicin
Cat.No: T1456
Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin
Target: Topoisomerase, AMPK
Luisol A
Cat.No: T73915
Synonym:
Target:
γ-Amanitin
Cat.No: T39562
Synonym:
Target:
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